Synthesis and Investigation of Chiral Poly(2,4-disubstituted-2-oxazoline)-Based Triblock Copolymers, Their Self-Assembly, and Formulation with Chiral and Achiral Drugs
نویسندگان
چکیده
Considering the largely chiral nature of biological systems, there is interest in drug delivery systems. Here, we investigate for first time polymer micelles based on poly(2-oxazoline) (POx) ABA-type triblock copolymers with and racemic hydrophobic blocks formulation achiral drugs. Specifically, poly(2-ethyl-4-ethyl-2-oxazoline) (pEtEtOx) poly(2-propyl-4-methyl-2-oxazoline) (pPrMeOx) were used as block B poly(2-methyl-2-oxazoline) (pMeOx) hydrophilic A. Using these copolymers, nanoformulations curcumin (CUR), paclitaxel (PTX), (R S) ibuprofen prepared. For CUR PTX, maximum loading was significantly dependent structure repeat units, but not chirality. In contrast, chiral/racemic affected neither by nor chirality, minor effects observed respect to size distribution drug-loaded micelles.
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ژورنال
عنوان ژورنال: Macromolecules
سال: 2022
ISSN: ['0024-9297', '1520-5835']
DOI: https://doi.org/10.1021/acs.macromol.2c00229